Playing hide and seek: Tumor cells in control of MHC class I antigen presentation

MHC class I (MHC-I) molecules present a blueprint of the intracellular proteome to T cells allowing them control infection or malignant transformation. As response, pathogens and tumor often downmodulate MHC-I mediated antigen presentation escape from immune surveillance. Although fundamental rules are known in detail, players this system not saturated new modules regulation have recently been uncovered. Here, we update understanding by how can be exploited tumors prevent exposure proteome. This knowledge provide ways improve responses against pathogens.